EGLN1 and Familial prostate cancer: Here, we demonstrated that the expression of PHD2 and FIH1 were decreased under hypoxic condition in PC-3 and DU145 cells, while inhibition of miR-182 could rescue it, suggesting that the downregulation of PHD2 and FIH1 upon hypoxia stress is partially due to the increased level of miR-182 in prostate cancer cells.