Using a reporter carrying TGFβ responsive motifs flanked by RUNX2 motifs (3x-multimerized TGFβRE-luciferase reporter), luciferase assays show that RUNX2 synergizes with TGFβ/SMADs to increase the promoter activity of the reporter in PC3-a prostate cancer cells [72]. This evidence concerns the gene TGFB1 and Familial prostate cancer.