Considering that RUNX2 immunoreactivity in colon carcinoma cells is associated with their aggressive clinical behavior in colon carcinoma patients [22], we propose that in a way similar to VSMC calcification, prevalent oxidative stress in cancer [46] could participate in maintaining high levels of RUNX2 through stimulation of the PI3K/AKT pathway. The gene discussed is PIK3CB; the disease is cancer.