CLU and early-onset autosomal dominant Alzheimer disease: On the other hand, UCHL1 and clusterin (Fig. 4e, f) have been described as important enhancers of neuroprotection and neurogenesis (e.g., neuronal process formation, elongation, and plasticity) as well as a potential target into some neurodegenerative disorders such as Alzheimer’s disease [67, 79–82].