SP110 and tuberculosis: This approach successfully identified multiple susceptibility loci and one gene Ipr1 (mouse) that alters macrophage necrosis and increases susceptibility, and helped to identify SP110 (the human homolog to mouse Ipr1) polymorphisms in TB-infected individuals (Kramnik et al., 1998, , 2000; Pan et al., 2005; Tosh et al., 2006; Yan et al., 2006; Kramnik, 2008; Pichugin et al., 2009; Sissons et al., 2009).