Of these, a role for miR-708 was most compelling, with proven direct targeting of EYA3 by miRNA-708 [98], over-expression of miR-708 leading to reduced EYA3 expression, an inverse correlation of miR-708 and EYA3 levels in primary tumours, as well as increased ES cell sensitization to etoposide by either EYA3 silencing or miR-708 expression, mediated by increased apoptosis. This evidence concerns the gene EYA3 and neoplasm.