MMP14 and neoplasm: There is substantial evidence for a causal role of matrix metalloproteinases (MMPs), especially membrane-type 1 MMP (MT1-MMP, MMP-14), in mediating pericellular proteolysis of a large array of proteins that regulate cell properties such as adhesion, proliferation, and motility, which in turn enable tumor cells to become invasive and metastatic [18–25].