In contrast, IC50 of SNS-032 in ES2, the most sensitive ovarian cancer cell line among those without CCNE1 overexpression was 20.05 μM while IC50 of SNS-032 in OVCAR3, the least sensitive one among those with elevated CCNE1 expression was 0.53 μM (Figure 4C). This evidence concerns the gene CCNE1 and ovarian cancer.