CCNE1 and ovarian carcinoma: MTT assay showed that OVCAR429 was the most sensitive line to JNJ-7706621 among ovarian cancer cell lines without CCNE1 overexpression which had an IC50 of 0.55 μM while OVCAR5 was the least sensitive line among ovarian cancer cell lines with elevated CCNE1 expression which had an IC50 of 2.02 μM (Figure 4B).