To elucidate the mechanistic link between 4E-BP1 and CRC, we assessed the basal levels of 4E-BP1 in 6 colon cancer cell lines (SW480, SW620, Colo205, Caco-2, HCT116, and HT-29) and 1 normal colon cell line, CCD-18co, under normoxia and hypoxia. The gene discussed is EIF4EBP1; the disease is colonic neoplasm.