Since homozygosity for the risk allele for rs12927355 correlates with increased CLEC16A and SOCS1 expression in CD4+ T cells, but has no significant impact in CD8+ T cells, the increase of the CD4+/CD8+ T cell ratio in MS patients would lead to an even higher total T cell expression of CLEC16A and SOCS1 in MS patients homozygous for the risk allele compared to healthy controls with the same genotype. This evidence concerns the gene CD4 and myeloid sarcoma.