SOCS1 and myeloid sarcoma: Since homozygosity for the risk allele for rs12927355 correlates with increased CLEC16A and SOCS1 expression in CD4+ T cells, but has no significant impact in CD8+ T cells, the increase of the CD4+/CD8+ T cell ratio in MS patients would lead to an even higher total T cell expression of CLEC16A and SOCS1 in MS patients homozygous for the risk allele compared to healthy controls with the same genotype.