When analyzing gene expression of CLEC16A, DEXI and SOCS1 in whole blood from common variable immunodeficiency patients, higher level of CLEC16A expression was only observed in the AA group (homozygous for the protective allele) of rs17806056, also in partial LD with rs12708716 (r2 = 0.555) [26]. Here, SOCS1 is linked to immune system disorder.