SIRT1 and metabolic dysfunction-associated steatotic liver disease: The aims of this study were as follows: (1) to test whether the signaling mechanisms underlying the proapoptotic activity of miR-34a are associated with the SIRT1/p66shc pathway in NAFLD; (2) to investigate whether CA activates SIRT1/p66shc by inhibiting miR-34a; and (3) to elucidate the role of the antiapoptotic effect of CA in protecting against NAFLD.