TP53 and cancer: Comparative analysis of stem cells reprogrammed by expressing c-Myc revealed genomic deletions and amplifications, characteristic of oncogene-induced DNA replication stress.79, 80 One of the critical effectors of c-Myc overexpression is the major mammalian tumor suppressor TP53.81 TP53 is the guardian of genome protecting the organism from cancer as well as infertility or aging.82, 83