Comparative analysis of stem cells reprogrammed by expressing c-Myc revealed genomic deletions and amplifications, characteristic of oncogene-induced DNA replication stress.79, 80 One of the critical effectors of c-Myc overexpression is the major mammalian tumor suppressor TP53.81 TP53 is the guardian of genome protecting the organism from cancer as well as infertility or aging.82, 83. This evidence concerns the gene MYC and neoplasm.