PAX7 and familial pancreatic carcinoma: In rodents, cancer cachexia is associated with muscle damage and deregulation of Pax7 expression in SCs and interstitial cells, through increased NF-κB activity,125 suggesting that NF-κB may contribute to muscle wasting in cancer.125 In muscle biopsies from pancreatic cancer patients with accelerated weight loss, an increased number of Pax7+ cells was observed, indicating that cancer cachexia is associated with an expansion of the myogenic precursor pool.125 Expansion of the Sca1+ cell population that resemble mouse FAPs, was also observed in cachectic muscles from tumor-bearing mice.