Up to now, there are ~21 isoforms of Cxs that distribute in almost all human organs in tissue-specific patterns.17 Cx26, one of the most common isoforms of Cxs, is predominantly expressed in lung tissue.18, 19 Despite Cx26 has been considered as a potential tumor suppressor or chemotherapy sensitizer in some types of tumors,20, 21 Ito et al.22 found that Cx26 helps lung squamous cell carcinoma (SCC, one histological type of NSCLC), acquire aggressive phenotypes, lymph node metastasis, and poor prognosis, indicating that a potential role of Cx26 on the malignant development of SCC. Here, GJB2 is linked to squamous cell lung carcinoma.