To investigate the effect of MCT knockdown in in vivo tumour growth inhibition, tumours were collected at the end of the experiment (day 45) and examined by immunohistochemistry for the expression of MCT1, MCT4, CD147 and CAIX (Figure 5B, 5C), CD31 and Ki67 (Supplementary Figure S2D). This evidence concerns the gene PECAM1 and neoplasm.