By overexpression of miR-200 family members in an orthotopic xenograft model using the MDA-MB-231 LM2 cell line, Li and colleagues proved miR-200 to regulate tumor cell plasticity and metastasis [60] via suppression of actin-related genes such as moesin. Importantly, miR-200c plays a seemingly paradoxical role in cancer metastasis. Here, MSN is linked to neoplasm.