One other study, utilizing FSIVGTT to measure insulin sensitivity in premenopausal obese women showed a deterioration of insulin sensitivity after 3 weeks of a eucaloric HF diet vs a eucaloric LF diet,13 whereas other studies, in agreement with our results, have used a euglycemic hyperinsulinemic clamp to assess insulin sensitivity, which is the ‘gold standard’ for this outcome. This evidence concerns the gene INS and hydrops fetalis.