The candidate genes, too, showed an age effect, but despite it, significant increases in methylation were observed for SFRP1 (p < 0.0001) and SLC5A8 (p = 0.007) in the “over 50 group,” when stratified by the presence vs. absence of previously diagnosed CRC (Fig. 4). This evidence concerns the gene SFRP1 and colorectal carcinoma.