Among the individual markers, the frequency of specimens with hypermethylation of IGF2 and NEUROG1 was significantly increased in adenomas with low-grade dysplasia already (Fig. 1), including some with the predisposing MMR gene not silenced, yet, indicating that methylation of IGF2 and NEUROG1 may provide a marker of early colon oncogenesis. Here, IGF2 is linked to adenoma.