SFRP1 and colorectal carcinoma: SFRP1 was discussed above; SLC5A8 encodes a sodium transporter that directly influences the absorption of short-chain fatty acids (e.g., butyrate, a histone deacetylase inhibitor) from the apical membrane of the intestinal tract into the colon [42] and is frequently silenced in ACF and CRC by promoter methylation [43].