These neurofibroma types were studied using tissue-specific, biallelic, deletions of Nf1 in Nf1+/− mice (Chen et al., 2014b; Joseph et al., 2008; Le et al., 2009, 2011; Mayes et al., 2011; Ribeiro et al., 2013; Wu et al., 2008; Zhu et al., 2002). This evidence concerns the gene NF1 and plexiform neurofibroma.