It also has been reported that ABC-like DLBCL more frequently exhibited JAK-STAT and NF-κB pathways activation compared with GCB-like DLBCL49, 50 Interestingly, Kato et al. demonstrated that NF-κB and JAK-STAT pathways were more remarkably activated in EBV positive DLBCL compared with ABC-like EBV negative DLBCL47. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.