In the case of esophageal squamous cell carcinoma (ESCC) and CDDP, the overexpression of multidrug-resistant protein gene (MRP1/2) (9,10) and the zinc ribbon domain-containing-1 (ZNRD1) (7) have been reported to be involved in this resistance. The gene discussed is POLR1H; the disease is esophageal squamous cell carcinoma.