Unlike AKAP12, Ezrin expression and increased malignancy seem to correlate in various human cancers, including uterine cervical cancer [53], uveal malignant melanoma [65], tongue SCC [86], hepatocellular carcinoma [49], brain astrocytoma [66], and atypical endometrial hyperplasia and uterine endometrioid adenocarcinoma [75]. This evidence concerns the gene AKAP12 and cancer.