TNF and Schnyder corneal dystrophy: Surprisingly, although stimulating endothelial cells with the inflammatory cytokine tumor necrosis factor – alpha (TNF-α) did expectedly lead to increased adhesion of SCD RBCs as compared to control conditions (Supplemental Fig. 6), TNF-α endothelial stimulation did not lead to increased SCD RBC adhesion as compared to the unstimulated case, which suggests that SCD RBCs alone are sufficient to cause this phenomenon.