For instance, it was previously reported that abnormal level of APOC3 led to hypertriglyceridemia in transgenic mice and humans (Carlson & Ballantyne, 1976; Ginsberg et al, 1986; Ito et al, 1990; Aalto-Setälä et al, 1992; Pollin et al, 2008). The gene discussed is APOC3; the disease is hypertriglyceridemia.