Also, in case of HIV-1 infection, the IFNα upregulated CD317(tetherin) inhibits the release of newly assembled virions [12, 13] whereas, tripartite-motif-containing 5α (TRIM5α) restricts the incoming HIV-1 capsid, which is also up regulated by Type 1 IFNs [14]. Here, BST2 is linked to HIV-1 infection.