TNF and Crohn disease: Also, in another study, expression of TLR8 was significantly increased in case of ulcerative colitis (350 folds) and Crohn’s disease (45 folds) thus suggesting role of inflammatory cytokines like TNFα in inflammatory bowel disease (IBD) [40] which could be fatal and in these clinical cases, if temporary halt is to be made then partial inhibition of MyD88 is needed.