NFKB1 and Alzheimer disease: We therefore chose to use gene set enrichment analysis (GSEA)18, 19 to analyse in the ageing datasets about the up-regulated AD DEGs in NOROS and NFKB Signalling pathways, and the down-regulated AD DEGs in Mitochondrial Dysfunction (MitoDys) and Oxidative Phosphorylation (OXPHOS) (see Methods).