32 of these AD DEGs are also enriched genes in ageing and include the NFKB complex components, NFKBIA, NFKB1 and RELA; the GWAS gene CLU; PPARA; and the TNF receptor superfamily members TNFRSF11B, TNFRSF1A and TNFRSF1B. Here, TNFRSF1B is linked to Alzheimer disease.