These include Production of the Nitric Oxide and Reactive Oxygen Species in Macrophages pathway (NOROS, adjPval = 1.26E-12, ratio = 44/180); NFKB Signalling (adjPval = 1.26E-11, ratio = 41/173); the Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis (adjPval = 1.26E-11, ratio = 56/298); LXR/RXR Activation (adjPval = 3.16E-11, ratio = 33/121); IL-8 Signalling (adjPval = 2.09E-10, ratio = 40/183) and B Cell Receptor Signalling (adjPval = 2.09E-10, ratio = 39/176). The gene discussed is NFKB1; the disease is rheumatoid arthritis.