Strong SENP1 immunostaining was significantly linked to advanced pathological tumor stage (p < 0.0001), high Gleason grade (p < 0.0001), presence of lymph node metastases (p = 0.0019) and high preoperative PSA-levels (p = 0.0037) when all tumors were jointly analyzed (Table 2). This evidence concerns the gene KLK3 and neoplasm.