PTEN and cancer: In earlier studies, we have identified other molecular markers that seemed to exert their prognostic impact only in specific molecularly defined subgroups such as in ERG positive and PTEN deleted cancers [49, 50], ERG negative cancers lacking PTEN deletion [51], ERG positive cancers [25], ERG negative cancers [52], cancers lacking PTEN deletion [53, 54], or in all cancers irrespective of ERG and PTEN status [55].