Compared with CNS hemangioblastoma, the results of immunohistochemical staining reported by many authors do not suggest a specific line of differentiation for RH tumours.16, 24–27 Markers currently used for these lesions include epithelial (cytokeratins), muscle (MSA, desmin, calponin), neural (S100 protein, neuron specific enolase) and other generic mesenchymal markers (vimentin); vimentin, S100 protein, NSE and inhibin are reported to express constantly in this tumour. The gene discussed is DES; the disease is neoplasm.