The determination of cytokines expression showed in animals treated with HMGB1 blocking antibodies lower expression of the pro-inflammatory cytokines IFNγ, TNFα and IL-17 during the first week of infection, while at day 14 the expression of these proinflammatory cytokines increased and the transcription of IL-10 was significant lower than control mice. Here, HMGB1 is linked to infection.