Considering that along the course of TB there are necrotic, apoptotic and stressed cells which should release HMGB in different redox states, the contribution of this alarmin in the immunopathology of TB could be important.The present study is aimed to evaluate the kinetics, cellular sources and function of HMGB1 in a model of pulmonary TB in BALB/c mice. The gene discussed is HMGB1; the disease is pulmonary tuberculosis.