For example, recent findings show that, while there is an approximately 50% reduction in COMT mRNA, protein, and enzyme activity levels in 22q11DS patients overall, COMT haplotypes containing SNPs in the 3’ untranslated region modulate the effect of the Val158Met genotype on COMT expression and enzyme activity [68]. The gene discussed is COMT; the disease is 22q11.2 deletion syndrome.