We present three examples from the myc tagged protein data, including ZBTB20 (for which the sumoylated form is more resistant to loss in mSLS4 than wt virus infection, while the major band is relatively unchanged), MBD1 (for which all forms are reduced to a lesser extent in the mSLS4 compared to wt infection), and ZBTB10 (for which the major band is equally sensitive in the two infections while the abundance of likely sumoylated species increases) (Fig 11). Here, ZBTB20 is linked to viral infectious disease.