CALCA and infection: In addition to KC and RANTES, which remained significantly higher in transgenic mice both at 2h and 24h post-infection (Fig 6E and 6F), MIP-1β, MCP-1, TNF-α, MIP-1α and KC peaked at 2h post-infection; levels of MIP-1β, MCP-1, TNF-α, MIP-1α and KC were also significantly increased in hu-C4BPxFH tg compared to wt mice (Fig 6A–6E) at 2h post-infection.