CD36 and obesity due to melanocortin 4 receptor deficiency: For example in the obesity category, the fatty acid translocase Cd36, which aids in free fatty acid (FFAs) uptake and contributes to hepatic steatosis [68] and fatty acid binding protein Fabp4 that helps maintain hepatic metabolic balance and links diet induced obesity to insulin resistance [69,70] was increased in SO-HFD, while fatty acid binding protein 5 (Fabp5), which plays an important role in detoxifying FFAs and preventing lipid dysregulation [71], was decreased three-fold (S1 Dataset).