MR1 and HIV infectious disease: Although Vα7.2-Jα33 MAIT cells form the overwhelming majority of the blood MAIT cell population in most people, Vα7.2-Jα12 and Vα7.2-Jα20 MAIT cells can comprise up to 50% in some individuals.10,31 Vα7.2-Jα12 MAIT cells also appear to be enriched in some tissues, although in most donors Vα7.2-Jα33 MAIT cells still predominate.31 Nonetheless, given that Vα7.2-Jα12, Vα7.2-Jα20, and Vα7.2-Jα33 MAIT cell TCRs all bind to ligand-bound MR1,10 there is no a priori reason to hypothesize that different subsets are differentially depleted in HIV infection compared with HCs.