To confirm that MAIT cells are depleted in HIV infection and that Vα7.2+CD161− cells are not significantly enriched, we reanalyzed our previously published data from the Swiss HIV Cohort Study excluding CD4+ T cells.13 Comparison of the pretreatment timepoint with HCs demonstrated a significant depletion of Vα7.2+CD161++ cells as a proportion of CD3+CD4− lymphocytes (1.10% vs 4.59% in HIV+ vs HC, P = 0.002) (Figure 3A). This evidence concerns the gene CD4 and HIV infectious disease.