PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In conclusion, this study provided preliminary findings demonstrating that the PNPLA3 rs738409 genotypes are associated with the risk of NAFLD and decline of the eGFR in normal weight subjects, thus suggesting that even though carriers of the PNPLA3 G/G genotype may have a normal weight status, they should nevertheless be carefully monitored for the presence of NAFLD, a decline in the renal function and associated complications.