The PNPLA3-related NAFLD was characterized by absolute and relative deficiencies of circulating triacylglycerols compared to obesity-related NAFLD, thus suggesting that the PNPLA3 polymorphism may impair lipolysis rather than stimulate the synthesis of intrahepatocellular triacylglycerols [29]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.