PNPLA3 and obesity due to melanocortin 4 receptor deficiency: The PNPLA3-related NAFLD was characterized by absolute and relative deficiencies of circulating triacylglycerols compared to obesity-related NAFLD, thus suggesting that the PNPLA3 polymorphism may impair lipolysis rather than stimulate the synthesis of intrahepatocellular triacylglycerols [29].