Musso et al. recently suggested that the presence of the PNPLA3 rs738409 polymorphism was associated with a lower estimated glomerular filtration rate (eGFR) and a higher prevalence of microalbuminuria and chronic kidney disease through a cross-sectional study [18], however, there is presently no data available regarding the longitudinal influence of PNPLA3 polymorphism on the renal function, including the relationship to weight status. Here, PNPLA3 is linked to chronic kidney disease.