According to the findings of the present study and these previous studies, we speculate that the relationship between the PNPLA3 polymorphism and the impaired lipolysis may be more pronounced in the normal weight subjects than in overweight subjects, thus resulting in the increased risk for NAFLD among the normal weight subjects with the PNPLA3 rs738409 G/G genotype. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.