An additional mutation (MYH7-p.Arg1045His) was found in family B in patients II: 1 and II: 3; the proband (family B, II: 3) with the doubly heterozygous mutations displayed a more malignant clinical phenotype of cardiomyopathy (Figures 2(b) and 3(c)). This evidence concerns the gene MYH7 and cardiomyopathy.