Lower ROS levels regulate the responseof cardiac myocytes to hypertrophic stimuli;however, at later stage of cardiac hypertrophy whenROS levels significantly exceed the capacity of anantioxidant defense system such as superoxide dismutase(SOD), glutathione peroxidase (GPOX) andcatalase (CAT), it leads to the myocardial dysfunctionand/or injury (9). This evidence concerns the gene SOD1 and cardiac hypertrophy.