Therefore,there is a positive relationship between the levelof IGF-1 and BMD in thalassemic patients (47).According to research, reduction of IGF-1 plays arole in glucocorticoid-induced osteoporosis (48).GH stimulates the production of BMP and OPG,causing increased proliferation of osteoblasts andinhibition of osteoclast production, respectively(6, 8). This evidence concerns the gene GH1 and osteoporosis.