Of these 41 CpGs, two were statistically significantly associated with eczema risk in both generations (Table 4); cg04850479 in the PROZ gene showed adjusted risk ratio (RR) of 15.19 (95 % confidence interval (CI) 1.71 to 79.50) in the F1 and 6.82 (95 % CI 1.52 to 30.62) in the F2 and cg01427769 in the NEU1 gene showed adjusted RR of 0.13 (95 % CI 0.03 to 0.46) in the F1 and 0.09 (95 % CI 0.03 to 0.36) in the F2. Here, PROZ is linked to Eczematoid dermatitis.