The remainder of the significantly enriched pathways included several pathways mechanistically linked to epithelial barrier integrity and cell adhesion, which are of key importance in eczema: examples include cadherins (protocadherin gamma, P = 1.8 × 10−16; cadherin 6 domain, P = 1.5 × 10−10; and cadherin N-terminal domain, P = 3.6 × 10−10), gap junctions (P = 2.6 × 10−6), cell adhesion (cell-cell adhesion, P = 2.7 × 10−10; cell adhesion, P = 2.2 × 10−5), tight junctions (P = 1.6 × 10−5), melanogenesis (P = 7.1 × 10−5), and apoptosis (P = 7.3 × 10−3). The gene discussed is CDH6; the disease is Eczematoid dermatitis.