Nevertheless, it is consistent with a number of reports that IL-17A, either overexpressed in vivo through specific vectors [16] or produced endogenously as part of immune responses in wild-type [29] or mutant mice [30], has a negative effect on eosinophilia, which parallels its ability to interact with hemopoietic growth factors, such as GM-CSF [22] and G-CSF [24]. The gene discussed is CSF2; the disease is Increased total eosinophil count.