Moreover, in preclinical experiments the effect of treatment with recombinant IL-22 [88], anti-IL-20, or anti-IL-20RA monoclonal antibody [77] was demonstrated to inhibit TGF-β production or the excessive accumulation of ECM components in mouse models of liver fibrosis induced by chemical agents (CCl4) or mechanical bile duct ligation. Here, TGFB1 is linked to Hepatic fibrosis.