IL19 and chronic kidney disease: Elevated urinary level of IL-19 [70] and IL-20 [74] was observed in patients with CKD. In vitro treatment of human renal proximal tubular epithelial cells with nephrotoxic agents, including Adefovir, Dipivoxil, Cisplatin, or Ifosfamide, was shown to induce the expression of IL-19 [70].