DNAJB6 and amyotrophic lateral sclerosis: Since hyperformation or persistence of stress granules, or stress granule-related complexes, appear to be causative in some neurodegenerative diseases such as ALS and some muscle myopathies (Li et al. 2013; Ramaswami et al. 2013), one possibility is that these mutations in DNAJB6 lead to a reduced ability to clear stress granules by autophagy, which could contribute to the degenerative disease.