In this study, we demonstrated that cooperation of DOT1L with c-Myc-p300 is importantfor regulation of both the EMT and CSC in breast cancer by epigenetic activation ofEMT-TFs, providing a novel mechanism of epigenetic regulation of DOT1L-mediatedtranscription of EMT enhancers (Fig. 5e). Here, DOT1L is linked to breast carcinoma.