The morphological analysisindicated that the lungs of control mice had numerous variable-sizedinfiltrative nodules composed of atypical cells, while the lungs of xenograftmice with DOT1L-knockdown cells showed well-preserved bronchiolar and alveolarstructures without evidence of metastatic carcinoma (Fig.1h, left). The gene discussed is DOT1L; the disease is metastatic carcinoma.