Furthermore, the high DOT1L expression levelin the ER-negative invasive ductal carcinoma subtype was associated withsignificantly worse overall survival (P=0.042,Gehan–Breslow–Wilcoxon tests; hazard ratio, 2.624) but nostatistically significant difference in recurrence (disease-free survival;P=0.184; Fig. 1a and Supplementary Table 2). Here, DOT1L is linked to invasive ductal breast carcinoma.