The upregulation of these EMT regulators by the DOT1L-c-Myc-p300complex enhances EMT-induced breast cancer stem cell (CSC)-like properties.Furthermore, in vivo orthotopic xenograft models show that DOT1L is requiredfor malignant transformation of breast epithelial cells and breast tumour initiationand metastasis. This evidence concerns the gene DOT1L and breast cancer.