The upregulation of these EMT regulators by the DOT1L-c-Myc-p300complex enhances EMT-induced breast cancer stem cell (CSC)-like properties.Furthermore, in vivo orthotopic xenograft models show that DOT1L is requiredfor malignant transformation of breast epithelial cells and breast tumour initiationand metastasis. The gene discussed is MYC; the disease is breast cancer.