The low IC50 values observed in most of our thyroid carcinoma cell lines as well as the lack of correlation of the GX15-070 sensitivity with expression of BAX and BAK and other proteins of the BCL-2 family provided first hints on possible other mechanisms of molecular action of GX15-070 in thyroid carcinoma cells in addition to those of BH3 mimetic activity as also discussed by others [57, 58]. The gene discussed is BAK1; the disease is thyroid gland carcinoma.