After its MCT1- and NHE1-directed entry in oncogenic H-Ras-transformed bladder cancer cells, 3-BrPA activates the PARP and RIPK3/MLKL/Drp1 necrotic axes, presumably together with the RIPK3/MLKL/TRPM7, RIPK3/MLKL/NHE1 and RIPK3/SAPK/JNK necrotic subroutines, in RIPK1-independent manner. The gene discussed is TRPM7; the disease is urinary bladder cancer.