TP53 and urinary bladder carcinoma: Given the ability of PRIMA-1 to reactivate mutant p53 [36], RT4, T24 and T24-X cells were exposed to PRIMA-1, in the presence or absence of 3-BrPA, examining the proficiency of endogenous mutant p53 (ΔY126), upon its functional restoration, to sensitize bladder cancer cells to 3-BrPA.