3-BrPA seems to selectively target high-grade bladder cancer cells that are addicted to oncogenic H-Ras, constitutive autophagy, aberrant PI3K/Akt/MAPK signaling and MCT1/NHE1 “pumping” activity, and can also tolerate lack of glucose for normal growth and survival. The gene discussed is AKT1; the disease is urinary bladder carcinoma.