Our results suggest that MMP1-1607 1G/2G, MMP2-1306 C/T, MMP2-735 C/T, MMP9 -1562 C/T polymorphisms were significantly associated with lung cancer risk among Asian population, but there is no association found between MMP13 -77A/G polymorphism and susceptibility to lung cancer. This evidence concerns the gene MMP9 and lung cancer.