In addition, we observed an increase in IL-6Rα levels in tumour cells and soluble IL-6R serum levels (Supplementary Fig. 1a–c) as well as increased Stat3, IL-6Rα and IL-6 mRNA levels (Supplementary Fig. 1d) in Ptenpc−/− PCa compared with WT controls. This evidence concerns the gene IL6R and posterior cortical atrophy.