MKI67 and posterior cortical atrophy: Like Ptenpc−/−Stat3pc−/− mice, Ptenpc−/−IL-6−/− mice showed markedly enhanced PCa growth (Supplementary Fig. 8c,d) at 19 weeks of age, increased Ki-67+ but decreased CC3+ expression levels compared with Ptenpc−/− prostates (Fig. 5e–g).