Interestingly, although PKCi was able to prevent PMA-induced increase in G6PD activity (Fig. 6B, compare hatched bars) as well as the production of NET (Fig. 6C, compare hatched bars), PKCi did not interfere with the AF-induced increase in G6PD activity (Fig. 6B, compare gray bars) or the associated NET production (Fig. 6C, compare gray bars). The gene discussed is G6PD; the disease is atrial fibrillation.