Interestingly, another study showed that the long-lasting incretin hormone analogue d-Ala2GIP (glucose-dependent insulinotropic polypeptide) was able to decrease OS biomarkers (i.e., 8-OHG) and amyloid plaque load in 12- and 19-month-old APPswe/PS1 mice [258]. This evidence concerns the gene GIP and amyloidosis.