TGFB1 and Miyoshi myopathy: (1) and (2), and thus the inhibition of TGF‐β indirectly suppresses the progression of MM cells, because immature osteoblast cells facilitate the growth and survival of MM cells, while mature cells enhance apoptosis of MM cells. In addition, TGF‐β can also promote the apoptosis of active osteoclasts as shown in Eq. (3). In the model of 3, the concentration of TGF‐β is defined as follows:(8)TGFβ=α·Kres·OCa+STGFβD ̃TGFβ.