The underlying mechanism for the indirect effect of bisphosphonate treatment lies in the fact that bisphosphonate therapy suppresses bone resorption, and thus results in a decrease in TGF‐β release, which then inhibits the proliferation of MM cells by suppressing IL‐6 secretion, because IL‐6 promotes the proliferation of MM cells 5, 8, 27, 28. This evidence concerns the gene TGFB1 and Miyoshi myopathy.