Furthermore, analyses of the TCGA GBM (https://tcga-data.nci.nih.gov/tcga/tcgaCancerDetails.jsp?diseaseType=GBM&diseaseName=Glioblastoma%20multiforme) and GSE16011 datasets [18] (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-16011/?query=GSE16011) also showed that patients with high TMEM140 protein expression had a significantly shorter overall survival rate time (TCGA, P = 0.008; GSE16011, P = 0.016; Fig. 1e, f). The gene discussed is TMEM140; the disease is glioblastoma.